For the world champion, Enzo Fernandez, Nicolas Tagliafico, and Nico Gonzalez scored, and captain Angel Di Maria picked up two assists.
Argentina, the defending world champions, defeated 10-man Bolivia 3-0 on Tuesday in La Paz despite resting Lionel Messi, continuing its unbeaten start to South American World Cup qualifying.
After scoring the game-winning goal in Thursday's 1-0 victory over Ecuador, Messi, who has had a busy schedule with his club Inter Miami, complained of being weary and watched his teammates from the bench. Messi was not listed as a substitute, though.
Lionel Scaloni's team had too much firepower for Bolivia despite the absence of their talisman; goals from Enzo Fernandez, Nicolas Tagliafico, and Nicolas Gonzalez sealed the victory.
Chelsea midfielder Fernandez came close with a fantastic shot from 30 yards out that Bolivian custodian Guillermo Viscarra deflected away.
Then, Viscarra performed admirably once more to block Julian Alvarez's close-range drive after he had taken advantage of some shoddy defence.
The energetic Alvarez contributed to Argentina's first goal in the 31st minute by supplying Angel Di Maria, whose low cross was converted by Fernandez, who had timed his run into the area precisely.
Bolivia's task became more difficult eight minutes later when Roberto Fernandez was sent for an excessive challenge on Cristian Romero.
Tagliafico's header that looped over Viscarra in response to a floating Di Maria free-kick gave Argentina a 2-0 lead at halftime.
After the break, the three-time World Cup champions were in complete control, with Viscarra being kept busy by shots from Rodrigo De Paul and Di Maria, and Alvarez hitting the post in the 70th minute.
After more poor defending from the home team, Gonzalez sealed the match seven minutes from time with a left-footed drive.
